HES3 Polyclonal Antibody

SKU: BT-AP09871

Size:100μL

Background:Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG).,The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related proteins.,Transcriptional repressor of genes that require a bHLH protein for their transcription.,Contains 1 basic helix-loop-helix (bHLH) domain.,Contains 1 Orange domain.,subunit:Transcription repression requires formation of a complex with a corepressor protein of the Groucho/TLE family.,

Research_area:Epigenetics and nuclear signaling

Target_protein:HES3

applications:WB, ELISA

Reactivity:Human, Mouse, Rat

Clonality:Polyclonal

Clone ID:

Host:Rabbit

Isotype:IgG

Gene Symbol/ Name:Transcription factor HES-3

Immunogen:The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage:-20°C for 1 year

Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration:1 mg/ml

Molecular weight(Da):

UniProt accession:Human: Q5TGS1; Mouse: Q61657; Rat: Q04667

Synonyms:Transcription factor HES-3 ;Class B basic helix-loop-helix protein 43;bHLHb43;Hairy and enhancer of split 3

GeneID:Human: 390992