GSK3B Monoclonal Antibody

SKU: BT-MCA3458

Size:100μL

Background:Glycogen synthase kinase 3 (GSK-3), a serine-threonine kinase with two isoforms (alpha and beta), was originally discovered as a key enzyme in glycogen metabolism. GSK-3 was subsequently shown to function in cell division, proliferation, motility and survival. GSK-3 plays a role in a number of pathological conditions including cancer and diabetes and is increasingly seen as an important component of neurological diseases. GSK-3 phosphorylates tau and presenilin-1, which are involved in the development of Alzheimer's disease. Both isoforms of GSK-3 are ubiquitously expressed, although particularly high levels of GSK-3beta are found in the brain where it is involved in synaptic plasticity, possibly via regulation of NMDA receptor trafficking. GSK-3 phosphorylates over 40 different substrates including signaling proteins, transcription factors and structural proteins, and is part of the signal transduction cascade of a large number of growth factors and cytokines. The activity of GSK is regulated by phosphorylation (Akt: Akt-mediated phosphorylation at Ser21 of GSK-3a and Ser9 of GSK-3

Research_area:Neuroscience

Target_protein:GSK3B

applications:WB, IHC, ICC, FCM

Reactivity:Human, Mouse, Monkey, Rat

Clonality:Monoclonal

Clone ID:3D10

Host:Mouse

Isotype:Mouse IgG2a

Gene Symbol/ Name:GSK3B

Immunogen:Purified recombinant fragment of human GSK3B expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Ascitic fluid containing 0.03% sodium azide.

Concentration:

Molecular weight(Da):46kDa

UniProt accession:P49841

Synonyms:GSK-3β, GSK3-beta

GeneID:2932