FH/Fumarase Mouse mAb

SKU: EM1156

Size: 100μL

Source:Mouse

Applications:WB, IF

Reactivity:Human, Rat, Mouse

Dilution:WB 1:1,000-3,000 IF 1:100-200

Immunogen:Recombinant Protein

Storage_stability:PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

Clonality:Monoclonal

Isotype:IgG1

Concentration:1mg/mL

Observed_band(KD):50kDa

Human_gene_id:2271

Human_swiss_prot_no:P07954

Subcellular_location:Cytoplasm, Mitochondrion

Other_name:Fumarase, fumarate hydratase, HLRCC, LRCC, MCL, MCUL1

Background:Fumarase (FH) is an enzyme that catalyzes the reversible hydration/dehydration of fumarate to malate. Fumarase comes in two forms: mitochondrial and cytosolic. The mitochondrial isoenzyme is involved in the Krebs Cycle (also known as the Tricarboxylic Acid Cycle [TCA] or the Citric Acid Cycle), and the cytosolic isoenzyme is involved in the metabolism of amino acids and fumarate. Subcellular localization is established by the presence of a signal sequence on the amino terminus in the mitochondrial form, while subcellular localization in the cytosolic form is established by the absence of the signal sequence found in the mitochondrial variety.