FADD antibody , Cat. # FNab02941

SKU: FNab02941

Size:100ug

Purification:Immunogen affinity purified

Form:liquid

Purity:?95% as determined by SDS-PAGE

Host:Rabbit

Clonality:polyclonal

Clone ID:

Isotype:IgG

Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)

Background:Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas(CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex(DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.

Immunogen:Fas(TNFRSF6)-associated via death domain

Synonyms:FADD, GIG3, MORT1, Protein FADD

Observed MW:26 kDa

Uniprot ID:Q13158

Reactivity:Human, Mouse, Rat

Tested Application:ELISA, IHC, WB, IP

Recommended dilution:WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IP: 1:50 - 1:200

Gene ID:8772

Research Area:Immunology, Signal Transduction