ESRRB Antibody, Biotin conjugated - Cat. #: CSB-PA007836LD01HU

SKU: CSB-PA007836LD01HU

Size :50ug

Clone Number:

Aliases:Err 2 antibody; ERR b antibody; ERR B2 antibody; ERR beta 2 antibody; ERR beta antibody; ERR beta-2 antibody; ERR-beta antibody; Err2 antibody; ERR2_HUMAN antibody; ERRB 2 antibody; ERRb antibody; ERRB2 antibody; ERRbeta 2 antibody; ERRbeta antibody; ESR L2 antibody; ESRL 2 antibody; ESRL2 antibody; Esrrb antibody; Estrogen receptor like 2 antibody; Estrogen receptor related 2 antibody; Estrogen receptor-like 2 antibody; Estrogen-related receptor beta antibody; Estrrb antibody; Nr3b2 antibody; Nuclear receptor ERRB2 antibody; Nuclear receptor subfamily 3 group B member 2 antibody; Orphan nuclear receptor antibody; Steroid hormone receptor ERR 2 antibody; Steroid hormone receptor ERR2 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:O95718

Immunogen:Recombinant Human Steroid hormone receptor ERR2 protein (432-502AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA

Background:Isoform 3: Transcription factor that binds a canonical ESRRB recognition (ERRE) sequence 5\'TCAAGGTCA-3\' localized on promoter and enhancer of targets genes regulating their expression or their transcription activity (PubMed:17920186, PubMed:19755138). Plays a role, in a LIF-independent manner, in maintainance of self-renewal and pluripotency of embryonic and trophoblast stem cells through different signaling pathways including FGF signaling pathway and Wnt signaling pathways. Upon FGF signaling pathway activation, interacts with KDM1A by directly binding to enhancer site of ELF5 and EOMES and activating their transcription leading to self-renewal of trophoblast stem cells. Also regulates expression of multiple rod-specific genes and is required for survival of this cell type (By similarity). Plays a role as transcription factor activator of GATA6, NR0B1, POU5F1 and PERM1 (PubMed:23836911). Plays a role as transcription factor repressor of NFE2L2 transcriptional activity and ESR1 transcriptional activity (PubMed:17920186, PubMed:19755138). During mitosis remains bound to a subset of interphase target genes, including pluripotency regulators, through the canonical ESRRB recognition (ERRE) sequence, leading to their transcriptional activation in early G1 phase. Can coassemble on structured DNA elements with other transcription factors like SOX2, POU5F1, KDM1A and NCOA3 to trigger ESRRB-dependent gene activation. This mechanism, in the case of SOX2 corecruitment prevents the embryonic stem cells (ESCs) to epiblast stem cells (EpiSC) transition through positive regulation of NR0B1 that inhibits the EpiSC transcriptional program. Also plays a role inner ear development by controlling expression of ion channels and transporters and in early placentation (By similarity).

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:Biotin

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:ESRRB

Research Areas:Epigenetics and Nuclear Signaling; Cancer; Developmental biology; Signal transduction