ELOB Antibody - Cat. #: CSB-PA620878ESR1HU

SKU: CSB-PA620878ESR1HU

Size :50ul

Clone Number:

Aliases:EloB antibody; ELOB_HUMAN antibody; Elongin 18 kDa subunit antibody; Elongin B antibody; Elongin-B antibody; RNA polymerase II transcription factor SIII p18 subunit antibody; RNA polymerase II transcription factor SIII subunit B antibody; SIII antibody; SIII p18 antibody; TCEB 2 antibody; Tceb2 antibody; Transcription elongation factor B (SIII) polypeptide 2 antibody; Transcription elongation factor B polypeptide 2 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q15370

Immunogen:Recombinant Human Elongin-B protein (1-118AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, WB, IHC; Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200

Background:SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex). The elongin BC complex seems to be involved as an adapter protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination complex CBC(VHL). By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes.

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antigen Affinity Purified

Conjugate:Non-conjugated

Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:ELOB

Research Areas:Epigenetics and Nuclear Signaling