Elab Fluor® 488-conjugated Lamin A/C Monoclonal Antibody

SKU: AN00298L

Size::25μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles. Protected from prolonged exposure to light.

Shipping:The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Tags/Controls Antibodies

Abbreviation:Lamin A/C

Target Synonym:Prelamin-A/C;LMNA;LMN1;Lamin A/C

Research Areas:Signal Transduction;Tags and Cell Markers;Cancer;Cell Biology;Developmental Biology;Epigenetics and Nuclear Signaling;Biochemicals

Conjugation:Elab Fluor®488

Host:Mouse

Species reactivity:Human

Application:IF

Isotype:IgG1

Clonality:Monoclonal

Clone NO.:4F1

UNIProt ID:P02545

Accession:

Background:Lamin A/C is also named as LMNA,or LMN1. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis,the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability,chromatin structure and gene expression. The lack of lamin A/C can be as a novel marker for undifferentiated embryonic stem cells and lamin A/C expression is as an early indicator of differentiation (PMID: 16179429). Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy,familial partial lipodystrophy,limb girdle muscular dystrophy,dilated cardiomyopathy,Charcot-Marie-Tooth disease,and Hutchinson-Gilford progeria syndrome. This protein has 4 isoforms produced by alternative splicing with the molecular weight of 74 kDa,65 kDa,70 kDa and 64 kDa. This antibody can recognize 4 isoforms of Lamin A/C.

Concentration:1 mg/mL

Immunogen:Recombinant Human Lamin A/C protein expressed by E.coli

Buffer:PBS with 0.02% sodium azide,1% protective protein and 50% glycerol,pH7.4

Purification method:Protein A/G Purification

Dilution:IF 1:100-1:200

Calculated MW:

ObservedMW: