E2F1 Antibody - Cat. #: CSB-PA922981

SKU: CSB-PA922981

Size :100ul

Clone Number:

Aliases:Dmel\CG6376 antibody; Dmel_CG6376 antibody; drosE2F1 antibody; E(Sev-CycE)3A antibody; E(var)3-93E antibody; E2-promoter binding facto antibody; E2F 1 antibody; E2F transcription factor 1 antibody; E2F-1 antibody; E2f-PA antibody; E2f-PB antibody; E2f-PC antibody; E2F1 antibody; E2f1 E2F transcription factor 1 antibody; E2F1_HUMAN antibody; Evar(3)164 antibody; KIAA4009 antibody; l(3)07172 antibody; l(3)j3B1 antibody; l(3)j3C2 antibody; l(3)rM729 antibody; mKIAA4009 antibody; OTTHUMP00000030661 antibody; PBR3 antibody; PRB binding protein E2F 1 antibody; PRB-binding protein E2F-1 antibody; RBAP 1 antibody; RBAP-1 antibody; RBAP1 antibody; RBBP-3 antibody; RBBP3 antibody; RBP 3 antibody; RBP3 antibody; Retinoblastoma-associated protein 1 antibody; Retinoblastoma-binding protein 3 antibody; Transcription factor E2F1 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q01094

Immunogen:Peptide sequence around aa.430~434(G-D-L-T-P) derived from Human E2F-1

Raised in:Rabbit

Species Reactivity:Human, Mouse

Tested Applications:ELISA, WB; WB:1:500-1:1000

Background:

Transcription activator that binds DNA cooperatively with dp proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F-1 binds preferentially RB1 protein, in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent apoptosis. "P53 and E2F-1 cooperate to mediate apoptosis."

Wu X., Levine A.J. Proc. Natl. Acad. Sci. U.S.A. 91:3602-3606(1994) "Regulation of E2F1 activity by acetylation."
Martinez-Balbas M.A., Bauer U.M., Nielsen S.J., Brehm A., Kouzarides T. EMBO J. 19:662-671(2000) "Regulation of E2F1 function by the nuclear corepressor KAP1."
Wang C., Rauscher F.J. III, Cress W.D., Chen J. J. Biol. Chem. 282:29902-29909(2007)

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Conjugate:Non-conjugated

Buffer:Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:E2F1

Research Areas:Epigenetics and Nuclear Signaling;Cancer