DROSHA Polyclonal Antibody

SKU: E-AB-17893

Size: 200μL

Storage: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping: The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

Exp date: 12 months

Category ID_II: Primary Antibodies

Category ID_III: Polyclonal Antibodies

Abbreviation: DROSHA

Target Synonym: DROSHA;Drosha double stranded RNA specific endoribonuclease;Drosha ribonuclease type III;Etohi2;HSA242976;Nuclear RNase III Drosha;p241;Protein Drosha;Putative protein p241 which interacts with transcription factor Sp1;Putative ribonuclease III;RANSE3L;Ribonuclease 3;Ribonuclease III;Ribonuclease III nuclear;Ribonuclease type III nuclear;RibonucleaseIII;RN 3;RN3;RNase 3;RNase III;RNase3;RNASE3L;RNaseIII;RNASEN;RNC

Research Areas: Cancer;Epigenetics and Nuclear Signaling

Conjugation: Unconjugated

Host: Rabbit

Species reactivity: Human;Mouse

Application: IHC

Isotype: IgG

Clonality: Polyclonal

Clone NO.:

UNIProt ID: Q9NRR4

Accession:

Background: This gene encodes a ribonuclease (RNase) III double-stranded RNA-specific ribonuclease and subunit of the microprocessor protein complex, which catalyzes the initial processing step of microRNA (miRNA) synthesis. The encoded protein cleaves the stem loop structure from the primary microRNA (pri-miRNA) in the nucleus, yielding the precursor miRNA (pre-miRNA), which is then exported to the cytoplasm for further processing. In a human cell line lacking a functional copy of this gene, canonical miRNA synthesis is reduced. Somatic mutations in this gene have been observed in human patients with kidney cancer. DROSHA (Drosha Ribonuclease III) is a Protein Coding gene. Diseases associated with DROSHA include Combat Disorder and Murray Valley Encephalitis. Among its related pathways are mRNA Capping and Gene Expression. GO annotations related to this gene include poly(A) RNA binding and RNA binding.

Concentration: 1.74 mg/mL

Immunogen: Synthetic peptide of human DROSHA

Buffer: PBS with 0.05% NaN3 and 40% Glycerol,pH7.4

Purification method: Antigen affinity purification

Dilution: IHC 1:30-1:150

Calculated MW:

ObservedMW: