Dok-2(Phospho Tyr345) Polyclonal Antibody

SKU: BT-AP08584

Size:100μL

Background:The protein encoded by this gene is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. This encoded protein binds p120 (RasGAP) from CML cells.

Research_area:Cancer; Signal transduction

Target_protein:DOK2

applications:IHC-p, IF, ELISA

Reactivity:Human, Mouse

Clonality:Polyclonal

Clone ID:

Host:Rabbit

Isotype:IgG

Gene Symbol/ Name:Docking protein 2

Immunogen:The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage:-20°C for 1 year

Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration:1 mg/ml

Molecular weight(Da):45379

UniProt accession:Human: O60496; Mouse: O70469

Synonyms:Docking protein 2; DOK2; Docking protein 2; Downstream of tyrosine kinase 2; p56;dok-2

GeneID:Human: 9046; Mouse: 13449