DMRT1 Antibody - Cat. #: CSB-PA896914LA01HU

SKU: CSB-PA896914LA01HU

Size :50ug

Clone Number:

Aliases:CT154 antibody; DM domain expressed in testis 1 antibody; DM domain expressed in testis protein 1 antibody; DM domain gene expressed in testis antibody; DMRT 1 antibody; dmrt1 antibody; DMRT1_HUMAN antibody; DMT 1 antibody; DMT1 antibody; Doublesex and mab 3 related transcription factor 1 antibody; Doublesex- and mab-3-related transcription factor 1 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q9Y5R6

Immunogen:Recombinant Human Doublesex- and mab-3-related transcription factor 1 protein (195-363AA)

Raised in:Rabbit

Species Reactivity:Human, Mouse

Tested Applications:ELISA, WB, IHC; Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200

Background:Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and male germ cell proliferation. Plays a central role in spermatogonia by inhibiting meiosis in undifferentiated spermatogonia and promoting mitosis, leading to spermatogonial development and allowing abundant and continuous production of sperm. Acts both as a transcription repressor and activator: prevents meiosis by restricting retinoic acid (RA)-dependent transcription and repressing STRA8 expression and promotes spermatogonial development by activating spermatogonial differentiation genes, such as SOHLH1. Also plays a key role in postnatal sex maintenance by maintaining testis determination and preventing feminization: represses transcription of female promoting genes such as FOXL2 and activates male-specific genes. May act as a tumor suppressor. May also play a minor role in oogenesis (By similarity).

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:Non-conjugated

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:DMRT1

Research Areas:Epigenetics and Nuclear Signaling