DHX58 Polyclonal Antibody

SKU: E-AB-19088

Size: 200μL

Storage: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping: The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

Exp date: 12 months

Category ID_II: Primary Antibodies

Category ID_III: Polyclonal Antibodies

Abbreviation: DHX58

Target Synonym: D11LGP2;D11lgp2e;DEXH (Asp Glu X His) box polypeptide 58;DEXH box polypeptide 58;DHX 58;DHX58;DHX58;LGP 2;LGP2;Ortholog of mouse D11lgp2;Probable ATP dependent helicase LGP2;Probable ATP dependent RNA helicase DHX58;Probable ATP-dependent helicase LGP2;Probable ATP-dependent RNA helicase DHX58;Protein D11Lgp2 homolog;RIG-I-like receptor LGP2;RLR;RNA helicase LGP2

Research Areas: Cancer;Epigenetics and Nuclear Signaling;Immunology

Conjugation: Unconjugated

Host: Rabbit

Species reactivity: Human;Rat

Application: WB;IHC

Isotype: IgG

Clonality: Polyclonal

Clone NO.:

UNIProt ID: Q96C10

Accession:

Background: Acts as a regulator of DDX58/RIG-I and IFIH1/MDA5 mediated antiviral signaling. Cannot initiate antiviral signaling as it lacks the CARD domain required for activating MAVS/IPS1-dependent signaling events. Can have both negative and positive regulatory functions related to DDX58/RIG-I and IFIH1/MDA5 signaling and this role in regulating signaling may be complex and could probably depend on characteristics of the infecting virus or target cells, or both. Its inhibitory action on DDX58/RIG-I signaling may involve the following mechanisms: competition with DDX58/RIG-I for binding to the viral RNA, binding to DDX58/RIG-I and inhibiting its dimerization and interaction with MAVS/IPS1, competing with IKBKE in its binding to MAVS/IPS1 thereby inhibiting activation of interferon regulatory factor 3 (IRF3). Its positive regulatory role may involve unwinding or stripping nucleoproteins of viral RNA thereby facilitating their recognition by DDX58/RIG-I and IFIH1/MDA5. Involved in the innate immune response to various RNA viruses and some DNA viruses such as poxviruses, and also to the bacterial pathogen Listeria monocytogenes. Can bind both ssRNA and dsRNA, with a higher affinity for dsRNA. Shows a preference to 5'-triphosphorylated RNA, although it can recognize RNA lacking a 5'-triphosphate.

Concentration: 1.02 mg/mL

Immunogen: Fusion protein of human DHX58

Buffer: PBS with 0.05% NaN3 and 40% Glycerol,pH7.4

Purification method: Antigen affinity purification

Dilution: WB 1:500-1:2000;IHC 1:50-1:100

Calculated MW: 77 kDa

ObservedMW: Refer to figures