DDIT3 Monoclonal Antibody

SKU: BT-MCA3272

Size:100μL

Background:This gene encodes a member of the CCAAT/enhancer-binding protein (C/EBP) family of transcription factors. The protein functions as a dominant-negative inhibitor by forming heterodimers with other C/EBP members, such as C/EBP and LAP (liver activator protein), and preventing their DNA binding activity. The protein is implicated in adipogenesis and erythropoiesis, is activated by endoplasmic reticulum stress, and promotes apoptosis. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in myxoid liposarcomas or Ewing sarcoma. Multiple alternatively spliced transcript variants encoding two isoforms with different length have been identified.

Research_area:Epigenetics and Nuclear Signaling

Target_protein:DDIT3

applications:IHC, ICC, FCM

Reactivity:Human

Clonality:Monoclonal

Clone ID:4E8E9

Host:Mouse

Isotype:Mouse IgG2a

Gene Symbol/ Name:DDIT3

Immunogen:Purified recombinant fragment of human DDIT3 (AA: 87-192) expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Purified antibody in PBS with 0.05% sodium azide.

Concentration:

Molecular weight(Da):19.2kDa

UniProt accession:P35638

Synonyms:CHOP, CEBPZ, CHOP10, CHOP-10, GADD153

GeneID:1649