Cyclin T2 rabbit pAb

SKU: ES17150

Size: 100μL

Source:Rabbit

Applications:IHC;IF;WB

Reactivity:Human; Mouse; Rat

Dilution:IHC-p 1:50-200, WB 1:500-2000

Immunogen:Synthesized peptide derived from human Cyclin T2 AA range: 510-590

Storage_stability:-20°C/1 year

Clonality:Polyclonal

Isotype:IgG

Concentration:1 mg/ml

Observed_band(KD):73kD

Human_gene_id:905

Human_swiss_prot_no:O60583

Subcellular_location:Cytoplasm, perinuclear region . Nucleus . Nucleus in differentiating cells. .

Other_name:Cyclin-T2 (CycT2)

Background:The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin and its kinase partner CDK9 were found to be subunits of the transcription elongation factor p-TEFb. The p-TEFb complex containing this cyclin was reported to interact with, and act as a negative regulator of human immunodeficiency virus type 1 (HIV-1) Tat protein. A pseudogene of this gene is found on chromosome 1. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010],