CRTC2 Antibody - Cat. #: CSB-PA706631LA01HU

SKU: CSB-PA706631LA01HU

Size :50ug

Clone Number:

Aliases:CREB regulated transcription coactivator 2 antibody; CREB-regulated transcription coactivator 2 antibody; CRTC2 antibody; CRTC2_HUMAN antibody; RP11-422P24.6 antibody; TORC-2 antibody; torc2 antibody; Transducer of CREB protein 2 antibody; Transducer of regulated cAMP response element-binding protein antibody; Transducer of regulated cAMP response element-binding protein (CREB) 2 antibody; Transducer of regulated cAMP response element-binding protein 2 antibody; Transducer of regulated CREB protein 2 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q53ET0

Immunogen:Recombinant Human CREB-regulated transcription coactivator 2 protein (180-372AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200

Background:Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 \'Ser-133\' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR).

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:Non-conjugated

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:CRTC2

Research Areas:Epigenetics and Nuclear Signaling; Neuroscience; Cancer; Metabolism; Signal transduction