CRGA Rabbit Polyclonal Antibody

SKU: BT-AP08445

Size:100μL

Background:Crystallins are separated into two classes: taxon-specific| or enzyme| and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development| these crystallins are made and then retained throughout life| making them extremely stable proteins. Mammalian lens crystallins are divided into alpha| beta| and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs| a connecting peptide| and N- and C-terminal extensions. Gamma-crystallins are a homogeneous group of highly symmetrical| monomeric proteins typically lacking connecting peptides and terminal extensions. They are differentially regulated after early development. Four gamma-crystallin genes (gamma-A through gamma-D) and three pseudogenes (gamma-E| gamma-F| gamma-G) are tandemly organized in a genomic segment as a gene cluster. Whether due to aging or mutations in specific genes| gamma-crystallins have been involved in cataract formation.

Research_area:Neuroscience

Target_protein:CRYGA

applications:WB

Reactivity:Human, Mouse, Rat

Clonality:Polyclonal

Clone ID:

Host:Rabbit

Isotype:IgG

Gene Symbol/ Name:CRGA

Immunogen:The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage:-20°C for 1 year

Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration:1 mg/ml

Molecular weight(Da):19140

UniProt accession:Human: P11844; Mouse: P04345; Rat: P10065

Synonyms:CRGA

GeneID:Human: 1418; Mouse: 12964; Rat: 684028