CPSF4 Antibody - Cat. #: CSB-PA282084

SKU: CSB-PA282084

Size :50ul

Clone Number:

Aliases:cleavage and polyadenylation specific factor 4; 30kDa antibody; Cleavage and polyadenylation specificity factor 30 kDa subunit antibody; Cleavage and polyadenylation specificity factor subunit 4 antibody; cleavage polyadenylation specificity factor; 30kD antibody; CPSF 30 kDa subunit antibody; CPSF30 antibody; Cpsf4 antibody; CPSF4_HUMAN antibody; NAR antibody; Neb-1 antibody; NEB1 antibody; No arches homolog antibody; no arches like zinc finger protein antibody; NS1 effector domain binding protein 1 antibody; NS1 effector domain-binding protein 1 antibody; OTTHUMP00000206235 antibody; OTTHUMP00000206237 antibody; OTTHUMP00000206239 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:O95639

Immunogen:Fusion protein of Human CPSF4

Raised in:Rabbit

Species Reactivity:Human, Mouse, Rat

Tested Applications:ELISA, IHC; ELISA:1:1000-1:2000, IHC:1:25-1:100

Background:Inhibition of the nuclear export of poly(A)-containing mRNAs caused by the influenza A virus NS1 protein requires its effector domain. The NS1 effector domain functionally interacts with the cellular 30 kDa subunit of cleavage and polyadenylation specific factor 4, an essential component of the 3' end processing machinery of cellular pre-mRNAs. In influenza virus-infected cells, the NS1 protein is physically associated with cleavage and polyadenylation specific factor 4, 30kD subunit. Binding of the NS1 protein to the 30 kDa protein in vitro prevents CPSF binding to the RNA substrate and inhibits 3' end cleavage and polyadenylation of host pre-mRNAs.

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antigen affinity purification

Conjugate:Non-conjugated

Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:CPSF4

Research Areas:Epigenetics and Nuclear Signaling;Microbiology