CP27B Polyclonal Antibody

SKU: BT-AP15083

Size:100μL

Background:This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the inner mitochondrial membrane where it hydroxylates 25-hydroxyvitamin D3 at the 1alpha position. This reaction synthesizes 1alpha,25-dihydroxyvitamin D3, the active form of vitamin D3, which binds to the vitamin D receptor and regulates calcium metabolism. Thus this enzyme regulates the level of biologically active vitamin D and plays an important role in calcium homeostasis. Mutations in this gene can result in vitamin D-dependent rickets type I.

Research_area:Metabolism

Target_protein:CYP27B1

applications:WB, ELISA

Reactivity:Human, Mouse, Rat

Clonality:Polyclonal

Clone ID:

Host:Rabbit

Isotype:IgG

Gene Symbol/ Name:25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial

Immunogen:The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage:-20°C for 1 year

Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration:1 mg/ml

Molecular weight(Da):

UniProt accession:Human: O15528; Mouse: O35084; Rat: O35132

Synonyms:25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial ;EC 1.14.13.13;25-OHD-1 alpha-hydroxylase;25-hydroxyvitamin D;3 1-alpha-hydroxylase;VD3 1A hydroxylase;Calcidiol 1-monooxygenase;Cytoc

GeneID:Human: 1594