Collagen Type IV antibody , Cat. # FNab01844

SKU: FNab01844

Size:100ug

Purification:Immunogen affinity purified

Form:liquid

Purity:?95% as determined by SDS-PAGE

Host:Rabbit

Clonality:polyclonal

Clone ID:

Isotype:IgG

Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)

Background:Type IV collagen is the major structural component of glomerular basement membranes(GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. Canstatin, a cleavage product corresponding to the collagen alpha 2(IV) NC1 domain, possesses both anti-angiogenic and anti-tumor cell activity. It inhibits proliferation and migration of endothelial cells, reduces mitochondrial membrane potential, and induces apoptosis. Specifically induces Fas-dependent apoptosis and activates procaspase-8 and-9 activity. Ligand for alphavbeta3 and alphavbeta5 integrins.

Immunogen:collagen, type IV, alpha 2

Synonyms:COL4A2, Collagen alpha 2(IV) chain, Collagen Type IV, collagen, type IV, alpha 2, DKFZp686I14213, FLJ22259

Observed MW:200 kDa

Uniprot ID:P08572

Reactivity:Human, Mouse, Rat

Tested Application:ELISA, IHC

Recommended dilution:IHC: 1:20-1:200

Gene ID:1284

Research Area:Cancer, Immunology