Collagen IV alpha2 (Cleaved-Ser1485) Rabbit Polyclonal Antibody

SKU: BT-AP01773

Size:100μL

Background:Alpha chains of type IV collagen have a non-collagenous domain (NC1) at their C-terminus| frequent interruptions of the G-X-Y repeats in the long central triple-helical domain (which may cause flexibility in the triple helix)| and a short N-terminal triple-helical 7S domain.|Type IV collagen is the major structural component of glomerular basement membranes (GBM)| forming a 'chicken-wire' meshwork together with laminins| proteoglycans and entactin/nidogen. Potently inhibits angiogenesis and tumor growth.|PTM:Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.|PTM:The trimeric structure of the NC1 domains may be stabilized by covalent bonds between Lys and Met residues.|PTM:Type IV collagens contain numerous cysteine residues which are involved in inter- and intramolecular disulfide bonding. 12 of these| located in the NC1 domain| are conserved in all known type IV collagens.|Belongs to the type IV collagen family.|Contains 1 collagen IV NC1 (C-terminal non-collagenous) domain.|subunit:There are six type IV collagen isoforms| alpha 1(IV)-alpha 6(IV)| each of which can form a triple helix structure with 2 other chains to generate type IV collagen network.|

Research_area:Cardiovascular; Signal transduction

Target_protein:COL4A2

applications:WB, ELISA

Reactivity:Human, Mouse

Clonality:Polyclonal

Clone ID:

Host:Rabbit

Isotype:IgG

Gene Symbol/ Name:Collagen IV alpha 2

Immunogen:The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage:-20°C for 1 year

Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration:1 mg/ml

Molecular weight(Da):188320

UniProt accession:Human: P08572; Mouse: P08122

Synonyms:Collagen IV α2 ;Cleaved-Ser1485; Collagen alpha-2;IV chain [Cleaved into: Canstatin;

GeneID:Human: 1284; Mouse: 12827