COL25A1 rabbit pAb

SKU: ES8542

Size: 100μL

Source:Rabbit

Applications:WB;ELISA

Reactivity:Human;Mouse

Dilution:WB 1:500-2000, ELISA 1:10000-20000

Immunogen:Synthetic peptide from human protein at AA range: 101-150

Storage_stability:-20°C/1 year

Clonality:Polyclonal

Isotype:IgG

Concentration:1 mg/ml

Observed_band(KD):64kD

Human_gene_id:84570

Human_swiss_prot_no:Q9BXS0

Subcellular_location:Membrane ; Single-pass type II membrane protein . After proteolytic cleavage, CLAC is secreted.

Other_name:COL25A1

Background:This gene encodes a brain-specific membrane associated collagen. A product of proteolytic processing of the encoded protein, CLAC (collagenous Alzheimer amyloid plaque component), binds to amyloid beta-peptides found in Alzheimer amyloid plaques but CLAC inhibits rather than facilitates amyloid fibril elongation (PMID: 16300410). A study of over-expression of this collagen in mice, however, found changes in pathology and behavior suggesting that the encoded protein may promote amyloid plaque formation (PMID: 19548013). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011],