COL1A2 Monoclonal Antibody

SKU: BT-MCA4142

Size:100μL

Background:This gene encodes the pro-alpha2 chain of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIB, recessive Ehlers-Danlos syndrome Classical type, idiopathic osteoporosis, and atypical Marfan syndrome. Symptoms associated with mutations in this gene, however, tend to be less severe than mutations in the gene for the alpha1 chain of type I collagen (COL1A1) reflecting the different role of alpha2 chains in matrix integrity. Three transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene.

Research_area:Signal Transduction

Target_protein:COL1A2

applications:ICC, FCM

Reactivity:

Clonality:Monoclonal

Clone ID:4D1A7

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:COL1A2

Immunogen:Purified recombinant fragment of human COL1A2 (AA: 23-79) expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Purified antibody in PBS with 0.05% sodium azide

Concentration:

Molecular weight(Da):129kDa

UniProt accession:P08123

Synonyms:OI4, EDSCV, EDSARTH2

GeneID:1278