CHD3 Monoclonal Antibody

SKU: BT-MCA3628

Size:100μL

Background:This gene encodes a member of the CHD family of proteins which are characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. This protein is one of the components of a histone deacetylase complex referred to as the Mi-2/NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromatin remodeling is essential for many processes including transcription. Autoantibodies against this protein are found in a subset of patients with dermatomyositis. Three alternatively spliced transcripts encoding different isoforms have been described.

Research_area:Epigenetics and nuclear signaling, Immunology

Target_protein:CHD3

applications:WB, IHC, ICC, FCM

Reactivity:Human, Mouse

Clonality:Monoclonal

Clone ID:2G4

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:CHD3

Immunogen:Purified recombinant fragment of human CHD3 expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Purified antibody in PBS with 0.05% sodium azide.

Concentration:

Molecular weight(Da):226kDa

UniProt accession:Q12873

Synonyms:ZFH, Mi-2a, Mi2-ALPHA, CHD3

GeneID:1107