CH25H Antibody, Biotin conjugated - Cat. #: CSB-PA005307LD01HU

SKU: CSB-PA005307LD01HU

Size :50ug

Clone Number:

Aliases:CH25H antibody; Cholesterol 25-hydroxylase antibody; EC 1.14.99.38 antibody; Cholesterol 25-monooxygenase antibody; h25OH antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:O95992

Immunogen:Recombinant Human Cholesterol 25-hydroxylase protein (142-272AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA

Background:Catalyzes the formation of 25-hydroxycholesterol from cholesterol, leading to repress cholesterol biosynthetic enzymes (PubMed:9852097). Plays a key role in cell positioning and movement in lymphoid tissues: 25-hydroxycholesterol is an intermediate in biosynthesis of 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC), an oxysterol that acts as a ligand for the G protein-coupled receptor GPR183/EBI2, a chemotactic receptor for a number of lymphoid cells. May play an important role in regulating lipid metabolism by synthesizing a corepressor that blocks sterol regulatory element binding protein (SREBP) processing. In testis, production of 25-hydroxycholesterol by macrophages may play a role in Leydig cell differentiation.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:Biotin

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:CH25H

Research Areas:Cancer; Cardiovascular; Cell biology; Metabolism