CDC14B antibody , Cat. # FNab01516

SKU: FNab01516

Size:100ug

Purification:Immunogen affinity purified

Form:liquid

Purity:?95% as determined by SDS-PAGE

Host:Rabbit

Clonality:polyclonal

Clone ID:

Isotype:IgG

Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)

Background:Dual-specificity phosphatase involved in DNA damage response. Essential regulator of the G2 DNA damage checkpoint: following DNA damage, translocates to the nucleus and dephosphorylates FZR1/CDH1, a key activator of the anaphase promoting complex/cyclosome(APC/C). Dephosphorylates SIRT2 around early anaphase. Dephosphorylation of FZR1/CDH1 activates the APC/C, leading to the ubiquitination of PLK1, preventing entry into mitosis. Preferentially dephosphorylates proteins modified by proline-directed kinases.

Immunogen:CDC14 cell division cycle 14 homolog B(S. cerevisiae)

Synonyms:

Observed MW:56 kDa

Uniprot ID:O60729

Reactivity:Human

Tested Application:ELISA, WB

Recommended dilution:WB: 1:500-1:2000

Gene ID:8555

Research Area:Cell Division and Proliferation, Metabolism