CD5 Mouse mAb

SKU: EM1071

Size: 100μL

Source:Mouse

Applications:IHC

Reactivity:Human, Rat, Mouse

Dilution:IHC 1:100-200

Immunogen:Synthetic Peptide

Storage_stability:PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

Clonality:Monoclonal

Isotype:IgG1

Concentration:1mg/mL

Observed_band(KD):

Human_gene_id:921

Human_swiss_prot_no:P06127

Subcellular_location:Membrane

Other_name:CD5 molecule, LEU1, Lymphocyte antigen T1/Leu 1, T1

Background:CD5 is a cluster of differentiation found on a subset of IgM-secreting B cells called B-1 cells, and also on T cells. B-1 cells have limited diversity of their B-cell receptor due to their lack of the enzyme terminal deoxynucleotidyl transferase (TdT) and are potentially self-reactive. CD5 serves to mitigate activating signals from the BCR so that the B-1 cells can only be activated by very strong stimuli (such as bacterial proteins) and not by normal tissue proteins.