CD243 Monoclonal Antibody

SKU: BT-MCA4216

Size:100μL

Background:The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. Mutations in this gene are associated with colchicine resistance and Inflammatory bowel disease 13. Alternative splicing and the use of alternative promoters results in multiple transcript variants.

Research_area:Others

Target_protein:CD243

applications:FCM

Reactivity:Human

Clonality:Monoclonal

Clone ID:4G6F4

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:CD243

Immunogen:Purified recombinant fragment of human CD243 (AA: 1149-1280) expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Purified antibody in PBS with 0.05% sodium azide

Concentration:

Molecular weight(Da):141.1kDa

UniProt accession:P08183

Synonyms:ABCB1, CLCS, MDR1, P-GP, PGY1, ABC20, GP170

GeneID:5243