CCND1 Antibody - Cat. #: CSB-PA446984

SKU: CSB-PA446984

Size :50ul

Clone Number:

Aliases:AI327039 antibody; B cell CLL/lymphoma 1 antibody; B cell leukemia 1 antibody; B cell lymphoma 1 protein antibody; B-cell lymphoma 1 protein antibody; BCL 1 antibody; BCL-1 antibody; BCL-1 oncogene antibody; BCL1 antibody; BCL1 oncogene antibody; ccnd1 antibody; CCND1/FSTL3 fusion gene antibody; CCND1/FSTL3 fusion gene; included antibody; CCND1/IGHG1 fusion gene antibody; CCND1/IGHG1 fusion gene; included antibody; CCND1/IGLC1 fusion gene antibody; CCND1/IGLC1 fusion gene; included antibody; CCND1/PTH fusion gene antibody; CCND1/PTH fusion gene; included antibody; CCND1_HUMAN antibody; cD1 antibody; Cyl 1 antibody; D11S287E antibody; G1/S specific cyclin D1 antibody; G1/S-specific cyclin-D1 antibody; Parathyroid adenomatosis 1 antibody; PRAD1 antibody; PRAD1 oncogene antibody; U21B31 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:P24385

Immunogen:Fusion protein of Human CCND1

Raised in:Rabbit

Species Reactivity:Human, Mouse, Rat

Tested Applications:ELISA, WB, IHC; ELISA:1:1000-1:5000, WB:1:500-1:2000, IHC:1:25-1:100

Background:The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antigen affinity purification

Conjugate:Non-conjugated

Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:CCND1

Research Areas:Epigenetics and Nuclear Signaling;Cancer;Cell biology