Canine Apolipoprotein E, APOE ELISA Kit

SKU: E0329Ca

Size:96 Tests-1 Kit

Background:APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density lipoproteins (IDL) but shows a preferential binding to high-density lipoproteins (HDL). It also binds a wide range of cellular receptors including the LDL receptor/LDLR and the very low-density lipoprotein receptor/VLDLR that mediate the cellular uptake of the APOE-containing lipoprotein particles. Finally, APOE has also a heparin-binding activity and binds heparan-sulfate proteoglycans on the surface of cells, a property that supports the capture and the receptor-mediated uptake of APOE-containing lipoproteins by cells.

Research_area:Signal Transduction; Cardiovascular

Applications:ELISA

Target_protein:APOE

Reactivity:Canine

Assay type:Sandwich

Sensitivity:9.91ng/mL

Detection range:20-4500ng/mL

Sample type:Serum, plasma or other biological fluids

Full product name:Apolipoprotein E

Species:Canine

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P18649

MASS(Da):37,224

GeneID:476438

Synonyms:APOE;Apo-E;Apolipoprotein E

Gene names:APOE

Standard solution:4800ng/mL