BUB3 antibody , Cat. # FNab00988

SKU: FNab00988

Size:100ug

Purification:Immunogen affinity purified

Form:liquid

Purity:?95% as determined by SDS-PAGE

Host:Rabbit

Clonality:polyclonal

Clone ID:

Isotype:IgG

Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)

Background:Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule(K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. Regulates chromosome segregation during oocyte meiosis. The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome(APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1.

Immunogen:budding uninhibited by benzimidazoles 3 homolog(yeast)

Synonyms:

Observed MW:

Uniprot ID:O43684

Reactivity:Human, Mouse, Rat

Tested Application:ELISA, IF

Recommended dilution:IF: 1:20-1:200

Gene ID:9184

Research Area:Cell Division and Proliferation