Bovine Suppressor of cytokine signaling 3,SOCS3 ELISA KIT

SKU: E0441Bo

Size:96 Tests-1 Kit

Background:SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including IL6ST/gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity and regulates IL6 signaling. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells (By similarity). Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). {ECO:0000250|UniProtKB:O14543, ECO:0000250|UniProtKB:O35718}.

Research_area:

Applications:ELISA

Target_protein:SOCS3

Reactivity:Bovine

Assay type:Sandwich

Sensitivity:0.94ng/L

Detection range:1.88-120ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:

Species:Bovine

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9BEG9

MASS(Da):25134

GeneID:282081

Synonyms:SOCS3

Gene names:SOCS3

Standard solution:240ng/L