Bovine Smarcc1 ELISA Kit

SKU: E0273Bo

Size:96 Tests-1 Kit

Background:Core component of the BAF (SWI/SNF) complex. This ATP-dependent chromatin-remodeling complex plays important roles in cell proliferation and differentiation, in cellular antiviral activities and inhibition of tumor formation. The BAF complex is able to create a stable, altered form of chromatin that constrains fewer negative supercoils than normal. This change in supercoiling would be due to the conversion of up to one-half of the nucleosomes on polynucleosomal arrays into asymmetric structures, termed altosomes, each composed of 2 histones octamers. Stimulates in vitro the remodeling activity of SMARCA4/BRG1/BAF190A. Plays a key role in cell-cycle control and causes cell cycle arrest in G0/G1. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity).

Research_area:Others

Applications:ELISA

Target_protein:SMARCC1

Reactivity:Bovine

Assay type:Sandwich

Sensitivity:0.023ng/ml

Detection range:0.05-10ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 1

Species:Bovine

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q5BIN2

MASS(Da):44,111

GeneID:537412

Synonyms:BAF47;BRG1-associated factor 47;SMARCC1;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

Gene names:SMARCB1

Standard solution:12.8ng/ml