Bovine hypoxia-inducible factor 1α,HIF-1α ELISA KIT

SKU: E2295Bo

Size:96 Tests-1 Kit

Background:Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease (By similarity). Heterodimerizes with ARNT; heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters (By similarity). Activation requires recruitment of transcriptional coactivators such as CREBBP and EP300. Activity is enhanced by interaction with NCOA1 and/or NCOA2. Interaction with redox regulatory protein APEX1 seems to activate CTAD and potentiates activation by NCOA1 and CREBBP. Involved in the axonal distribution and transport of mitochondria in neurons during hypoxia (By similarity). {ECO:0000250|UniProtKB:Q16665, ECO:0000250|UniProtKB:Q61221}.

Research_area:

Applications:ELISA

Target_protein:HIF1A

Reactivity:Bovine

Assay type:Sandwich

Sensitivity:0.55nmol/L

Detection range:1-300nmol/L

Sample type:Serum, plasma or other biological fluids

Full product name:hypoxia-inducible factor 1α

Species:Bovine

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9XTA5

MASS(Da):92128

GeneID:

Synonyms:HIF1A

Gene names:HIF1A

Standard solution:320nmol/L