Bovine Apoptosis regulator BAX,BAX ELISA KIT

SKU: E0456Bo

Size:96 Tests-1 Kit

Background:Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis. BAX deficiency leads to lymphoid hyperplasia and male sterility, because of the cessation of sperm production (By similarity). Interacts (via a C-terminal 33 residues) with NOL3 (via CARD domain); inhibits BAX activation and translocation and consequently cytochrome c release from mitochondria (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q63690}.

Research_area:

Applications:ELISA

Target_protein:BAX

Reactivity:Bovine

Assay type:Sandwich

Sensitivity:0.1ng/mL

Detection range:0.19-12ng/mL

Sample type:Serum, plasma or other biological fluids

Full product name:

Species:Bovine

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:O02703

MASS(Da):21259

GeneID:280730

Synonyms:BAX

Gene names:BAX

Standard solution:24ng/mL