BMX Antibody - Cat. #: CSB-PA991678

SKU: CSB-PA991678

Size :100ul

Clone Number:

Aliases:Bmx antibody; BMX non receptor tyrosine kinase antibody; BMX_HUMAN antibody; BONE MARROW KINASE; X-LINKED antibody; Bone marrow tyrosine kinase gene in chromosome X protein antibody; Cytoplasmic tyrosine protein kinase BMX antibody; Cytoplasmic tyrosine-protein kinase BMX antibody; Epithelial and endothelial tyrosine kinase antibody; ETK antibody; NKT38 antibody; NTK 38 antibody; NTK38 antibody; Protein tyrosine kinase BMX antibody; PSCTK 2 antibody; PSCTK 3 antibody; PSCTK2 antibody; PSCTK3 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:P51813

Immunogen:Synthesized peptide derived from N-terminal of Human BMX.

Raised in:Rabbit

Species Reactivity:Human, Mouse

Tested Applications:ELISA, WB, IHC, IF; WB:1:500-1:3000, IHC:1:50-1:100, IF:1:100-1:500

Background:Non-receptor tyrosine kinase that plays central but diverse modulatory roles in various signaling processes involved in the regulation of actin reorganization, cell migration, cell proliferation and survival, cell adhesion, and apoptosis. Participates in signal transduction stimulated by growth factor receptors, cytokine receptors, G-protein coupled receptors, antigen receptors and integrins. Induces tyrosine phosphorylation of BCAR1 in response to integrin regulation. Activation of BMX by integrins is mediated by PTK2/FAK1, a key mediator of integrin signaling events leading to the regulation of actin cytoskeleton and cell motility. Plays a critical role in TNF-induced angiogenesis, and implicated in the signaling of TEK and FLT1 receptors, 2 important receptor families essential for angiogenesis. Required for the phosphorylation and activation of STAT3, a transcription factor involved in cell differentiation. Also involved in interleukin-6 (IL6) induced differentiation. Plays also a role in programming adaptive cytoprotection against extracellular stress in different cell systems, salivary epithelial cells, brain endothelial cells, and dermal fibroblasts. May be involved in regulation of endocytosis through its interaction with an endosomal protein RUFY1. May also play a role in the growth and differentiation of hematopoietic cells; as well as in signal transduction in endocardial and arterial endothelial cells.

Tamagnone L., Oncogene 9:3683-3688(1994).
Qiu Y., Proc. Natl. Acad. Sci. U.S.A. 95:3644-3649(1998).
Fuortes M., Thesis (1994), Cornell University, United States.

Clonality:Polyclonal

Isotype:IgG

Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Conjugate:Non-conjugated

Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:BMX

Research Areas:Signal transduction