BMI1 Monoclonal Antibody

SKU: BT-MCA2235

Size:100μL

Background:Component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2.

Research_area:Epigenetics and nuclear signaling, Cancer, Cell biology, Stem cells

Target_protein:BMI1

applications:IHC, ICC, FCM

Reactivity:Human

Clonality:Monoclonal

Clone ID:3E3

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:BMI1

Immunogen:Purified recombinant fragment of human BMI1 expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Ascitic fluid containing 0.03% sodium azide.

Concentration:

Molecular weight(Da):37kDa

UniProt accession:P35226

Synonyms:PCGF4, RNF51, MGC12685, FLVI2/BMI1

GeneID:648