BCL2/Bcl-2 Monoclonal Antibody

SKU: AN200169P

Size::

Storage:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Monoclonal Antibodies

Abbreviation:BCL2

Target Synonym:B-cell Lymphoma;PPP1R;BCL;Bcl-2;PPP1R50;BCL2;apoptosis regulator Bcl-2;B-cell Lymphoma 2;apoptosis regulator Bcl-2;Bcl-2;PPP1R50;Apoptosis regulator Bcl 2;Apoptosis regulator Bcl2;AW986256;B cell CLL/lymphoma 2;B cell leukemia/lymphoma 2;B-cell;C430015F12Rik;D630044D05Rik;D830018M01Rik;Leukemia/lymphoma;Oncogene B-cell leukemia 2;Protein phosphatase 1;regulatory subunit 50;Bcl2

Research Areas:Cell Biology;Signal Transduction;Cancer;Kits;Lysates;Other;Metabolism

Conjugation:Unconjugated

Host:Mouse

Species reactivity:Human

Application:WB;IP

Isotype:IgG1

Clonality:Monoclonal

Clone NO.:6C10

UNIProt ID:P10415

Accession:

Background:Bcl-2 is a member of a family of proteins that regulates outer mitochondrial membrane permeability. Bcl-2 is an anti-apoptotic member that prevents release of cytochrome c from the mitochondria intermembrane space into the cytosol. Bcl-2 is present on the outer mitochondrial membrane and is also found on other membranes in some cell types. Natural Bcl-2 contains a carboxyl-terminal mitochondria targeting sequence. Recombinant Bcl-2, missing the mitochondrial targeting sequence, maintains its ability to neutralize pro-apoptotic Bcl-2 family members. Neutralization by Bcl-2 appears to be through binding the BH3 region of pro-apoptotic Bcl-2 family members. This activity does not require the mitochondrial targeting sequence.

Concentration:1 mg/mL

Immunogen:Recombinant Human BCL2/Bcl-2 protein

Buffer:0.2 μm filtered solution in PBS

Purification method:Protein A

Dilution:WB 1:500-1:2000;IP 1-4 μL/mg of lysate

Calculated MW:26 kDa

ObservedMW:27 kDa