BCL-x Polyclonal Antibody

SKU: E-AB-30640

Size: 200μL

Storage: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping: The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

Exp date: 12 months

Category ID_II: Primary Antibodies

Category ID_III: Polyclonal Antibodies

Abbreviation: Bcl-x

Target Synonym: Apoptosis regulator Bcl X;Apoptosis regulator Bcl-X;Apoptosis regulator BclX;B cell lymphoma 2 like;B2CL1;Bcl 2 like 1 protein;Bcl X;Bcl xL;BCL XL/S;Bcl xS;Bcl-2-like protein 1;Bcl2 Like 1;Bcl2 related gene;Bcl2-L-1;BCL2L;Bcl2l1;BCLX;BclXL;BclXs;DKFZp781P2092;PPP1R52;Protein phosphatase 1 regulatory subunit 52

Research Areas: Cancer;Cell Biology;Metabolism;Signal Transduction

Conjugation: Unconjugated

Host: Rabbit

Species reactivity: Human;Mouse;Rat

Application: WB;IHC-p;IF

Isotype: IgG

Clonality: Polyclonal

Clone NO.:

UNIProt ID: Q07817

Accession:

Background: Bcl x is a member of the Bcl 2 family of proteins, which function as regulators of apoptosis. It may provide neuroprotection against ischemic brian injury. Bcl x has two isoforms, Bcl xl (long) a 241 amino acid protein and Bcl xs (short) a 178 amino acid protein lacking a 63 amino acid domain that is well conserved among members of the Bcl2 family. Isoform Bcl-X(L) anti-apoptotic activity is inhibited by association with SIVA isoform 1. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channnel (VDAC) by binding to it and preventing the release of the caspase activator, cytochrome c, from the mitochondrial membrane. The Bcl-X(S) isoform promotes apoptosis.

Concentration: 1 mg/mL

Immunogen: Synthesized peptide derived from human Bcl-x around the non-phosphorylation site of Thr47.

Buffer: PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4

Purification method: Affinity purification

Dilution: WB 1:500-1:2000;IHC 1:100-1:300;IF 1:200-1:1000

Calculated MW: 26kDa

ObservedMW: 30kDa