ATP8A1 antibody , Cat. # FNab00728

SKU: FNab00728

Size:100ug

Purification:Immunogen affinity purified

Form:liquid

Purity:?95% as determined by SDS-PAGE

Host:Rabbit

Clonality:polyclonal

Clone ID:

Isotype:IgG

Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)

Background:Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. In vitro, its ATPase activity is selectively and stereospecifically stimulated by phosphatidylserine(PS). The flippase complex ATP8A1:TMEM30A seems to play a role in regulation of cell migration probably involving flippase-mediated translocation of phosphatidylethanolamine(PE) at the plasma membrane. Acts as aminophospholipid translocase at the plasma membrane in neuronal cells.

Immunogen:ATPase, aminophospholipid transporter(APLT), class I, type 8A, member 1

Synonyms:ATP8A1, ATPase II, ATPASEII, ATPIA, ATPP2, Chromaffin granule ATPase II

Observed MW:120kd

Uniprot ID:Q9Y2Q0

Reactivity:Human, Mouse, Rat

Tested Application:ELISA, WB

Recommended dilution:WB: 1:500-1:2000

Gene ID:10396

Research Area:Metabolism