ATP2C1 Monoclonal Antibody

SKU: BT-MCA2532

Size:100μL

Background:ATP2C1, also known as PMR1, it belongs to the family of P-type cation transport ATPases. This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium. The human homologue, ATP2C1 (also designated SPLA in rat), also regulates the transport of calcium in the Golgi complex and is related to other P-type ATPases family members, such as the sarco(endo)plasmic calcium ATPase (SERCA) and the plasma membrane calcium ATPase (PCMA). ATP2C1 is a transmembrane protein that exists as two splice variants, which vary by 20 amino acids. Defects in ATP2C1 cause Hailey-Hailey disease, which is an autosomal dominant disorder that is characterized by blisters and erosions of the skin. These findings provide further evidence that PMR1 plays a key role in maintaining the integrity of the epidermis by controlling intracellular calcium signaling.

Research_area:Signal transduction, Cardiovascular, Cell biology, Epigenetics and nuclear signaling

Target_protein:ATP2C1

applications:WB, IHC

Reactivity:Human, Monkey

Clonality:Monoclonal

Clone ID:4G12

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:ATP2C1

Immunogen:Purified recombinant fragment of ATP2C1 expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Ascitic fluid containing 0.03% sodium azide.

Concentration:

Molecular weight(Da):100kDa

UniProt accession:P98194

Synonyms:HHD, BCPM, PMR1, SPCA1

GeneID:27032