ATG13 Rabbit pAb

SKU: ES20862

Size: 100μL

Source:Rabbit

Applications:IHC;WB

Reactivity:Human; Mouse;Rat

Dilution:IHC-p1:50-200 ,WB 1:1000-2000

Immunogen:Synthesized peptide derived from human ATG13 AA range: 182-232

Storage_stability:-20°C/1 year

Clonality:Polyclonal

Isotype:IgG

Concentration:1 mg/ml

Observed_band(KD):72kD

Human_gene_id:9776

Human_swiss_prot_no:O75143

Subcellular_location:Cytoplasm, cytosol . Preautophagosomal structure . Under starvation conditions, is localized to puncate structures primarily representing the isolation membrane; the isolation membrane sequesters a portion of the cytoplasm resulting in autophagosome formation. .

Other_name:Autophagy-related protein 13

Background:Atg13 was identified as a constitutively expressed protein that was genetically linked to Atg1/Apg1, a protein kinase required for autophagy. Overexpression of Atg1 suppresses the defects in autophagy observed in Atg13 mutants. Autophagy requires a direct association between Atg1 and Atg13, and is inhibited by TOR-dependent phosphorylation of Atg13 under high-nutrient conditions.