ARRB1 Monoclonal Antibody

SKU: BT-MCA2250

Size:100μL

Background:Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described.

Research_area:Signal Transduction

Target_protein:ARRB1

applications:

Reactivity:Human

Clonality:Monoclonal

Clone ID:4E11B1

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:ARRB1

Immunogen:Purified recombinant fragment of human ARRB1 (AA: 89-268) expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Purified antibody in PBS with 0.05% sodium azide.

Concentration:

Molecular weight(Da):47kDa

UniProt accession:P49407

Synonyms:ARB1, ARR1

GeneID:408