APEX1 antibody , Cat. # FNab00479

SKU: FNab00479

Size:100ug

Purification:Immunogen affinity purified

Form:liquid

Purity:?95% as determined by SDS-PAGE

Host:Rabbit

Clonality:polyclonal

Clone ID:

Isotype:IgG

Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20? for 12 months (Avoid repeated freeze / thaw cycles.)

Background:Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes the major AP endonuclease in human cells. Splice variants have been found for this gene; all encode the same protein.

Immunogen:APEX nuclease (multifunctional DNA repair enzyme) 1

Synonyms:APE, APE1, APEX, APX, HAP1, REF1

Observed MW:39 kDa

Uniprot ID:P27695

Reactivity:Human

Tested Application:ELISA, WB, IP, IF

Recommended dilution:WB: 1:500 - 1:2000; IF: 1:50 - 1:100; IP: 1:50 - 1:200

Gene ID:328

Research Area:Cardiovascular, Metabolism