Anti-TRPV1 Antibody Picoband®

SKU: A00128-4

Size: 100 μg

Storage: At -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freezing and thawing.

Form: Lyophilized

Reactivity: Human,Rat

Applications: WB,ICC,IF,Flow Cytometry,ELISA

Application Details: Western blot, 0.25-0.5 μg/ml, Human, Rat
Immunocytochemistry/Immunofluorescence, 5 μg/ml, Human
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/ml, -

Gene Name: TRPV1

Specificity:

Background: The transient receptor potential cation channel, subfamily V, member 1(TRPV1), also known as the capsaicin receptor is a protein which in humans is encoded by the TRPV1 gene. TRPV1(also called Vanilloid receptor type 1) is a ligand-gated nonselective cation channel that is considered to be an important integrator of various pain stimuli such as endogenous lipids, capsaicin, heat, and low pH. In addition to expression in primary afferents, TRPV1 is also expressed in the CNS. Cui M et al.(2006) demonstrate that TRPV1 receptors in the CNS plays an important role in pain mediated by central sensitization. And the significant CNS penetration is necessary for a TRPV1 antagonist to produce broad-spectrum analgesia. And TRPV1 also participates in normal bladder function and is essential for normal mechanically evoked purinergic signaling by the urothelium.

Immunogen: E.coli-derived human TRPV1 recombinant protein (Position: E107-A800).

Clonality: Polyclonal

Contents: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Purification: Immunogen affinity purified.

Reconstitution: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Reference: 1. Bartoshuk, L. M., Duffy, V. B., Miller, I. J. PTC/PROP tasting: anatomy, psychophysics, and sex effects. Physiol. Behav. 56: 1165-1171, 1994. Note: Erratum: Physiol. Behav. 58: 203 only, 1995. 2. Basu, S., Srivastava, P. Immunological role of neuronal receptor vanilloid receptor 1 expressed on dendritic cells. Proc. Nat. Acad. Sci. 102: 5120-5125, 2005. 3. Bhave, G., Zhu, W., Wang, H., Brasier, D. J., Oxford, G. S., Gereau, R. W., IV. cAMP-dependent protein kinase regulates desensitization of the capsaicin receptor (VR1) by phosphorylation. Neuron 35: 721-731, 2002.

Uniprot ID: Q8NER1

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate:

Cross Reactivity: No cross-reactivity with other proteins.

Isotype: Rabbit IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 95 kDa

Calculated Molecular Weight:

Gene ID: 7442

Protein Name: Transient receptor potential cation channel subfamily V member 1

Gene Full Name: transient receptor potential cation channel subfamily V member 1

Synonyms: Capsaicin receptor; DKFZp434K0220; Osm 9 like TRP channel 1; OTRPC1; TRPV1; Vanilloid receptor 1; VR1