Anti-STAM2 Antibody Picoband®

SKU: A06533-3

Size: 100 μg

Storage: At -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freezing and thawing.

Form: Lyophilized

Reactivity: Human,Mouse,Rat

Applications: ELISA,IF,ICC,IHC,WB

Application Details: Western blot, 0.25-0.5 μg/ml, Human, Mouse, Rat
Immunohistochemistry (Paraffin-embedded Section), 2-5 μg/ml, Human
Immunocytochemistry/Immunofluorescence, 5 μg/ml, Human
ELISA, 0.1-0.5 μg/ml, -

Gene Name: STAM2

Specificity:

Background: Signal transducing adapter molecule 2 is a protein that in humans is encoded by the STAM2 gene. The protein encoded by this gene is closely related to STAM, an adaptor protein involved in the downstream signaling of cytokine receptors, both of which contain a SH3 domain and the immunoreceptor tyrosine-based activation motif (ITAM). Similar to STAM, this protein acts downstream of JAK kinases, and is phosphorylated in response to cytokine stimulation. This protein and STAM thus are thought to exhibit compensatory effects on the signaling pathway downstream of JAK kinases upon cytokine stimulation.

Immunogen: E.coli-derived human STAM2 recombinant protein (Position: K134-L525). Human STAM2 shares 82.7% and 79.6% amino acid (aa) sequence identity with mouse and rat STAM2, respectively.

Clonality: Polyclonal

Contents: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Purification: Immunogen affinity purified.

Reconstitution: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Reference: 1. Berlin, I., Schwartz, H., Nash, P. D. Regulation of epidermal growth factor receptor ubiquitination and trafficking by the USP8-STAM complex. J. Biol. Chem. 285: 34909-34921, 2010. 2. Endo, K., Takeshita, T., Kasai, H., Sasaki, Y., Tanaka, N., Asao, H., Kikuchi, K., Yamada, M., Chen, M., O'Shea, J. J., Sugamura, K. STAM2, a new member of the STAM family, binding to the Janus kinases. FEBS Lett. 477: 55-61, 2000. 3. Pandey, A., Fernandez, M. M., Steen, H., Blagoev, B., Nielsen, M. M., Roche, S., Mann, M., Lodish, H. F. Identification of a novel immunoreceptor tyrosine-based activation motif-containing molecule, STAM2, by mass spectrometry and its involvement in growth factor and cytokine receptor signaling pathways. J. Biol. Chem. 275: 38633-38639, 2000.

Uniprot ID: O75886

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate:

Cross Reactivity: No cross reactivity with other proteins.

Isotype: IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 65-70 kDa

Calculated Molecular Weight: 58 kDa

Gene ID: 10254

Protein Name: Signal transducing adapter molecule 2

Gene Full Name: signal transducing adaptor molecule 2

Synonyms: Hbp; Hrs binding protein; STAM 2; STAM2; STAM2A; STAM2B