Anti-RTKN2 Antibody Picoband®

SKU: A12576-1

Size: 100 μg

Storage: At -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freezing and thawing.

Form: Lyophilized

Reactivity: Human,Mouse,Rat

Applications: ELISA,Flow Cytometry,WB

Application Details: Western blot, 0.1-0.25 μg/ml, Human, Mouse, Rat
. Flow Cytometry (Fixed), 1-3 μg /1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/ml, -

Gene Name: RTKN2

Specificity:

Background: Rhotekin 2 is a protein in humans that is encoded by the RTKN2 gene. The RTKN2 gene encodes a protein known as Rhotekin-2, which is involved in various cellular processes, including cytoskeletal organization, cell migration, and signal transduction. RTKN2 interacts with Rho GTPases, particularly RhoA, and modulates their activity to regulate actin cytoskeleton dynamics and cell morphology. This protein plays a role in cell adhesion and migration, with implications for tissue development, wound healing, and cancer metastasis. Additionally, RTKN2 has been linked to synaptic plasticity and neuronal development in the brain. Dysregulation of RTKN2 expression or function has been associated with neurological disorders, cardiovascular diseases, and cancer progression. Elucidating the molecular mechanisms underlying RTKN2's diverse functions is crucial for understanding its physiological roles and its potential as a therapeutic target for various diseases.

Immunogen: E.coli-derived human RTKN2 recombinant protein (Position: M1-D572). Human RTKN2 shares 71.8% amino acid (aa) sequence identity with mouse RTKN2.

Clonality: Polyclonal

Contents: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Purification: Immunogen affinity purified.

Reconstitution: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Reference: 1. Collier, F. M., Gregorio-King, C. C., Gough, T. J., Talbot, C. D., Walder, K., Kirkland, M. A. Identification and characterization of a lymphocytic Rho-GTPase effector: rhotekin-2. Biochem. Biophys. Res. Commun. 324: 1360-1369, 2004. 2. Collier, F. M., Loving, A., Baker, A. J., McLeod, J., Walder, K., Kirkland, M. A. RTKN2 induces NF-kappaB dependent resistance to intrinsic apoptosis in HEK cells and regulates BCL-2 genes in human CD4+ lymphocytes. J. Cell Death 2: 9-23, 2009. Note: Electronic Article. 3. Gregorio-King, C. C., Gough, T., Van Der Meer, G. J., Hosking, J. B., Waugh, C. M., McLeod, J. L., Collier, F. M., Kirkland, M. A. Mechanisms of resistance to the cytotoxic effects of oxysterols in human leukemic cells. J. Steroid Biochem. Molec. Biol. 88: 311-320, 2004.

Uniprot ID: Q8IZC4

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate:

Cross Reactivity:

Isotype: IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 69 kDa

Calculated Molecular Weight: 69 kDa

Gene ID: 219790

Protein Name: Rhotekin-2

Gene Full Name: rhotekin 2

Synonyms: RTKN2; PLEKHK1; Rhotekin-2; Pleckstrin homology domain-containing family K member 1; PH domain-containing family K member 1