Anti-RRM1 Antibody Picoband®

SKU: A01764-2

Size: 100 μg

Storage: At -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freezing and thawing.

Form: Lyophilized

Reactivity: Human

Applications: WB,Flow Cytometry,ELISA

Application Details: Western blot, 0.25-0.5 μg/ml, Human
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/ml, -

Gene Name: RRM1

Specificity:

Background: Ribonucleoside-diphosphate reductase large subunit is an enzyme that in humans is encoded by the RRM1 gene. This gene encodes the large and catalytic subunit of ribonucleotide reductase, an enzyme essential for the conversion of ribonucleotides into deoxyribonucleotides. A pool of available deoxyribonucleotides is important for DNA replication during S phase of the cell cycle as well as multiple DNA repair processes. Alternative splicing results in multiple transcript variants.

Immunogen: E.coli-derived human RRM1 recombinant protein (Position: D129-Q730).

Clonality: Polyclonal

Contents: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Purification: Immunogen affinity purified.

Reconstitution: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Reference: 1. Brissenden, J. E., Caras, I., Thelander, L., Francke, U. The structural gene for the M1 subunit of human ribonucleotide reductase maps to chromosome 11, band p15, in human and to chromosome 7 in mouse. Exp. Cell Res. 174: 302-308, 1988. 2. Byrne, J. A., Smith, P. J. The 11p15.5 ribonucleotide reductase M1 subunit locus is not imprinted in Wilms' tumour and hepatoblastoma. Hum. Genet. 91: 275-277, 1993. 3. Byrne, J., Smith, P. Human polymorphic probe pE1.8 detects SacI polymorphism in the ribonucleotide reductase M1 subunit gene. Hum. Genet. 87: 376 only, 1991.

Uniprot ID: P23921

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate:

Cross Reactivity: No cross-reactivity with other proteins.

Isotype: Rabbit IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 90 kDa

Calculated Molecular Weight:

Gene ID: 6240

Protein Name: Ribonucleoside-diphosphate reductase large subunit

Gene Full Name: ribonucleotide reductase catalytic subunit M1

Synonyms: R1; ribonucleotide reductase M1; RIR1; RR1; RRM1