Anti-PLVAP Antibody Picoband®

SKU: A07024

Size: 100 μg

Storage: At -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freezing and thawing.

Form: Lyophilized

Reactivity: Human

Applications: WB,Flow Cytometry,ELISA

Application Details: Western blot, 0.25-0.5 μg/ml, Human
Flow Cytometry (Fixed), 1-3 μg/1x1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/ml, -

Gene Name: PLVAP

Specificity:

Background: Plasmalemma vesicle-associated protein is a protein that in humans is encoded by the PLVAP gene. Predicted to enable identical protein binding activity. Involved in MAPK cascade; positive regulation of cellular extravasation; and tumor necrosis factor-mediated signaling pathway. Located in cell surface. Colocalizes with caveola. Implicated in congenital diarrhea.

Immunogen: E.coli-derived human PLVAP recombinant protein (Position: N51-K422).

Clonality: Polyclonal

Contents: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Purification: Immunogen affinity purified.

Reconstitution: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Reference: 1. Broekaert, I. J., Becker, K., Gottschalk, I., Korber F., Dotsch, J., Thiele, H., Altmuller, J., Nurnberg, P., Hunseler, C., Cirak, S. Mutations in plasmalemma vesicle-associated protein cause severe syndromic protein-losing enteropathy.. J. Med. Genet. 55: 637-640, 2018. 2. Elkadri, A., Thoeni, C., Deharvengt, S. J., Murchie, R., Guo, C., Stavropoulos, J. D., Marshall, C. R., Wales, P., Bandsma, R. H. J., Cutz, E., Roifman, C. M., Chitayat, D., Avitzur, Y., Stan, R. V., Muise A. M. Mutations in plasmalemma vesicle associated protein result in sieving protein-losing enteropathy characterized by hypoproteinemia, hypoalbuminemia, and hypertriglyceridemia. Cell. Molec. Gastroent. Hepatol. 1: 381-394, 2015. 3. Herrnberger, L., Seitz, R., Kuespert, S., Bosl, M. R., Fuchshofer, R., Tamm, E. R. Lack of endothelial diaphragms in fenestrae and caveolae of mutant Plvap-deficient mice. Histochem. Cell Biol. 138: 709-724, 2012.

Uniprot ID: Q9BX97

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate:

Cross Reactivity: No cross-reactivity with other proteins.

Isotype: Rabbit IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 53 kDa

Calculated Molecular Weight:

Gene ID: 83483

Protein Name: Plasmalemma vesicle-associated protein

Gene Full Name: plasmalemma vesicle associated protein

Synonyms: FELS; gp68; Plasmalemma vesicle protein 1; PLVAP; PV 1; PV1