Anti-PLCG 2/PLCG2 Antibody Picoband®

SKU: A03572-1

Size: 100 μg

Storage: Store at -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freeze-thaw cycles.

Form: Lyophilized

Reactivity: Human

Applications: ELISA,Flow Cytometry,IF,IHC,ICC,WB

Application Details: Western blot,0.1-0.5μg/ml
Immunohistochemistry (Paraffin-embedded Section),2-5μg/ml
Immunocytochemistry/Immunofluorescence, 5 μg/ml
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells
ELISA,0.1-0.5μg/ml

Gene Name: PLCG2

Specificity: No cross reactivity with other proteins.

Background: 1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2 is an enzyme that in humans is encoded by the PLCG2 gene. The protein encoded by this gene is a transmembrane signaling enzyme that catalyzes the conversion of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to 1D-myo-inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) using calcium as a cofactor. IP3 and DAG are second messenger molecules important for transmitting signals from growth factor receptors and immune system receptors across the cell membrane. Mutations in this gene have been found in autoinflammation, antibody deficiency, and immune dysregulation syndrome and familial cold autoinflammatory syndrome 3.

Immunogen: E. coli-derived human PLCG 2 recombinant protein (Position: R1201-V1258).

Clonality: Polyclonal

Contents: Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Purification: Immunogen affinity purified.

Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Reference: 1. Entrez Gene: PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific). 2. Hernandez D, Egan SE, Yulug IG, Fisher EM (February 1995). Mapping the gene that encodes phosphatidylinositol-specific phospholipase C-gamma 2 in the human and the mouse. Genomics. 23 (2): 504–7.

Uniprot ID: P16885

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate: This is the unconjugated antibody. It is also available with 10 conjugation options, including Biotin, Cy3, Fluoro488, Fluoro550, Fluoro594, FITC, HRP, APC, PE, and Fluoro647. A carrier-free (BSA-free) version is also available. Additional charges may apply for some options. Please contact us for a quote

Cross Reactivity: No cross-reactivity with other proteins.

Isotype: Rabbit IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 148 kDa

Calculated Molecular Weight:

Gene ID: 5336

Protein Name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2

Gene Full Name: phospholipase C gamma 2

Synonyms: phospholipase C gamma 2; APLAID; FCAS3; PLC-IV; PLC-gamma-2; PLCG2; Phospholipase C IV; PLC gamma 2; PLC IV; PLC γ2; PLCγ2