Anti-PCDHGC3 Antibody Picoband®

SKU: A12828-1

Size: 100 μg

Storage: At -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freezing and thawing.

Form: Lyophilized

Reactivity: Human,Rat

Applications: WB,Flow Cytometry,ELISA

Application Details: Western blot, 0.25-0.5 μg/ml, Human, Rat
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/ml, -

Gene Name: PCDHGC3

Specificity:

Background: Protocadherin gamma-C3 is a protein that in humans is encoded by the PCDHGC3 gene. This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes.

Immunogen: E.coli-derived human PCDHGC3 recombinant protein (Position: E498-E804).

Clonality: Polyclonal

Contents: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Purification: Immunogen affinity purified.

Reconstitution: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Reference: 1. Sago, H., Kitagawa, M., Obata, S., Mori, N., Taketani, S., Rochelle, J. M., Seldin, M. F., Davidson, M., St. John, T., Suzuki, S. T. Cloning, expression, and chromosomal localization of a novel cadherin-related protein, protocadherin-3. Genomics 29: 631-640, 1995. 2. Sano, K., Tanihara, H., Heimark, R. L., Obata, S., Davidson, M., St. John, T., Taketani, S., Suzuki, S. Protocadherins: a large family of cadherin-related molecules in central nervous system. EMBO J. 12: 2249-2256, 1993. 3. Wu, Q., Maniatis, T. A striking organization of a large family of human neural cadherin-like cell adhesion genes. Cell 97: 779-790, 1999.

Uniprot ID: Q9UN70

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate:

Cross Reactivity: No cross reactivity with other proteins.

Isotype: IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 118 kDa

Calculated Molecular Weight: 52588 MW

Gene ID: 5098

Protein Name: Protocadherin gamma-C3

Gene Full Name: protocadherin gamma subfamily C, 3

Synonyms: PC 43; PC43; PCDH GAMMA C3; PCDH2; PCDHGC3; Protocadherin 2; Protocadherin 43; Protocadherin gamma C3